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An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance.
Hagenbeek TJ, Zbieg JR, Hafner M, Mroue R, Lacap JA, Sodir NM, Noland CL, Afghani S, Kishore A, Bhat KP, Yao X, Schmidt S, Clausen S, Steffek M, Lee W, Beroza P, Martin S, Lin E, Fong R, Di Lello P, Kubala MH, Yang MN, Lau JT, Chan E, Arrazate A, An L, Levy E, Lorenzo MN, Lee HJ, Pham TH, Modrusan Z, Zang R, Chen YC, Kabza M, Ahmed M, Li J, Chang MT, Maddalo D, Evangelista M, Ye X, Crawford JJ, Dey A. Hagenbeek TJ, et al. Among authors: lorenzo mn. Nat Cancer. 2023 Jun;4(6):812-828. doi: 10.1038/s43018-023-00577-0. Epub 2023 Jun 5. Nat Cancer. 2023. PMID: 37277530 Free PMC article.
Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.
Misaghi S, Senger K, Sai T, Qu Y, Sun Y, Hamidzadeh K, Nguyen A, Jin Z, Zhou M, Yan D, Lin WY, Lin Z, Lorenzo MN, Sebrell A, Ding J, Xu M, Caplazi P, Austin CD, Balazs M, Roose-Girma M, DeForge L, Warming S, Lee WP, Dixit VM, Zarrin AA. Misaghi S, et al. Among authors: lorenzo mn. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15770-5. doi: 10.1073/pnas.1221661110. Epub 2013 Sep 9. Proc Natl Acad Sci U S A. 2013. PMID: 24019479 Free PMC article.
Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis.
Sun Y, Peng I, Senger K, Hamidzadeh K, Reichelt M, Baca M, Yeh R, Lorenzo MN, Sebrell A, Dela Cruz C, Tam L, Corpuz R, Wu J, Sai T, Roose-Girma M, Warming S, Balazs M, Gonzalez LC, Caplazi P, Martin F, Devoss J, Zarrin AA. Sun Y, et al. Among authors: lorenzo mn. Autoimmunity. 2013 Mar;46(2):157-67. doi: 10.3109/08916934.2012.750301. Epub 2013 Jan 18. Autoimmunity. 2013. PMID: 23167594 Free PMC article.
Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers.
Parikh C, Janakiraman V, Wu WI, Foo CK, Kljavin NM, Chaudhuri S, Stawiski E, Lee B, Lin J, Li H, Lorenzo MN, Yuan W, Guillory J, Jackson M, Rondon J, Franke Y, Bowman KK, Sagolla M, Stinson J, Wu TD, Wu J, Stokoe D, Stern HM, Brandhuber BJ, Lin K, Skelton NJ, Seshagiri S. Parikh C, et al. Among authors: lorenzo mn. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19368-73. doi: 10.1073/pnas.1204384109. Epub 2012 Nov 7. Proc Natl Acad Sci U S A. 2012. PMID: 23134728 Free PMC article.
Increased targeting of donor switch region and IgE in Sgamma1-deficient B cells.
Misaghi S, Garris CS, Sun Y, Nguyen A, Zhang J, Sebrell A, Senger K, Yan D, Lorenzo MN, Heldens S, Lee WP, Xu M, Wu J, DeForge L, Sai T, Dixit VM, Zarrin AA. Misaghi S, et al. Among authors: lorenzo mn. J Immunol. 2010 Jul 1;185(1):166-73. doi: 10.4049/jimmunol.1000515. Epub 2010 May 28. J Immunol. 2010. PMID: 20511552